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Proceedings Paper

Activation of angiogenesis under influence of red low level laser radiation
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Paper Abstract

Activation of angiogenesis under laser irradiation is one of the feasible explanations for long lasting treatment effects of laser therapy. The aim of the current study is the investigation of red low level laser light influence on angiogenesis study in vitro, and comparison with effects of vascular endothelial growth factor (VEGF) application. The study was done on rat thoracic aortal rings. Samples of group 1 served as control, group 2 samples were incubated with VEGF, group 3 samples were irradiated with low level laser (660 nm, 20 mW) during 10 min, and group 4 samples were incubated with VEGF and received 10 min of laser irradiation. Low level laser irradiation activates the process of angiogenesis. In the control group angiogenesis of new vessels was not detected. Laser irradiation promoted angiogenesis. The area covered by new vessels was 1,9±0,29 mm2 and the maximal length of vessels was 0,75±0,lO mm. No statistical difference was discovered between laser irradiation and VEGF application. After combined influence of VEGF and laser light irradiation the area covered by new vessels was 6,98±0,88 mm2 and the maximal length of vessels was 1,7±0,23 mm. So, laser irradiation can intensify effects of VEGF on angiogenesis.

Paper Details

Date Published: 25 October 2005
PDF: 6 pages
Proc. SPIE 5968, Laser Florence 2004: A Window on the Laser Medicine World, 596806 (25 October 2005); doi: 10.1117/12.660039
Show Author Affiliations
Levon V. Gasparyan, EMRED Oy (Finland)
Grigory Brill, Saratov State Medical Univ. (Russia)
Anu M. Makela, ABER Institute (Finland)

Published in SPIE Proceedings Vol. 5968:
Laser Florence 2004: A Window on the Laser Medicine World
Leonardo Longo; Khalil A. Khatri; Mihail-Lucian Pascu; Wilhelm R.A. Waidelich, Editor(s)

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