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Proceedings Paper

A model for corneal endothelial morphometry by diffraction
Author(s): Curry Bucht; Per Söderberg; Göran Manneberg
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Paper Abstract

As a part of an ongoing project on corneal endothelium morphometry by diffraction, a model for corneal endothelium simulation has been developed. The model has been developed in the mathematical programming language Matlab. Images of corneal endothelium were simulated and the diffraction pattern of the image was calculated. The diffraction pattern was calculated for a series of endothelial images while varying important variables in the simulated image. This rendered the theoretical relationships between values of variables in the diffraction pattern and values of morphometric variables in the image. At this stage, the analysis focused on the expression of endothelial mean cell size and coefficient of variation in the diffraction pattern, respectively. As expected from diffraction theory, it was found that there is a direct linear relationship between mean cell size and distance between periodic variations in the diffraction pattern. We further found that the ratio between the intensity in the central maximum and the intensity in the first harmonic of the diffraction pattern was functionally depending on the variation in cell size. The current findings demonstrate that it is possible to theoretically determine average cell size and coefficient of variation of cell size in the diffraction pattern.

Paper Details

Date Published: 7 March 2006
PDF: 8 pages
Proc. SPIE 6138, Ophthalmic Technologies XVI, 61380O (7 March 2006); doi: 10.1117/12.660023
Show Author Affiliations
Curry Bucht, St. Erik's Eye Hospital (Sweden)
Royal Institute of Technology (Sweden)
Per Söderberg, St. Erik's Eye Hospital (Sweden)
Mälarsjukhuset Eskilstuna (Sweden)
Univ. of Miami (United States)
Göran Manneberg, Royal Institute of Technology (Sweden)

Published in SPIE Proceedings Vol. 6138:
Ophthalmic Technologies XVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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