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Proceedings Paper

Enhanced optical clearing of human skin at topical application of immersion agents to stratum corneum pretreated by a lattice-like photothermal ablation
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Paper Abstract

High level of light scattering in mammalian skin significantly deteriorates the effectiveness and precision of light delivery to intra- and subcutaneous targets in therapeutic and diagnostic applications. Optical immersion based on the refractive index matching of tissue scattering centers with surrounding matter via introduction of an exogenous indexmatching agent is capable to alleviate the problem. But this process goes slowly enough because of sluggish diffusion of various immersion agents through a stratum corneum (SC) barrier, making a practical realization of this approach difficult. In order to increase the rate of the process we designed the method of accelerating the penetration of optical clearing agents (OCAs) by enhancing skin permeability through a creation of lattice-like pattern of localized thermal damage (ablation) islets in the SC. OCAs, such as glucose, propylene glycol, and glycerol solutions, were applied. Experimental results show a remarkable increase in the rate of optical clearing. The most of results were obtained on in vivo human skin.

Paper Details

Date Published: 22 February 2006
PDF: 12 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60780V (22 February 2006); doi: 10.1117/12.660015
Show Author Affiliations
Valery V. Tuchin, Saratov State Univ. (Russia)
Gregory B. Altshuler, Palomar Medical Technologies Inc. (United States)
Anna A. Gavrilova, Saratov State Univ. (Russia)
Alexander B. Pravdin, Saratov State Univ. (Russia)
David Tabatadze, Palomar Medical Technologies Inc. (United States)
Jim Childs, Palomar Medical Technologies Inc. (United States)
Ilya V. Yaroslavsky, Palomar Medical Technologies Inc. (United States)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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