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Proceedings Paper

Selectivity of optical stimulation in the auditory system
Author(s): Agnella D. Izzo; Jyoti Pathria; Eul Suh; Joseph T. Walsh; Donna S. Whitlon; E. Duco Jansen; Claus-Peter Richter
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Paper Abstract

It is known that electrical current injected from cochlear implant contacts spreads within the cochlea, causing overlapping stimulation fields and possibly limiting the performance of cochlear implant users. We have investigated an alternative mechanism to stimulate auditory neurons in the gerbil cochlea using a laser, rather than electrical current. With the laser, it is possible to direct the light to a selected, known volume of tissue that is smaller than the electrically stimulated population of cells. In the present experiments, a transiently expressed transcription factor, c-FOS, was used to stain activated nerve cells. Immunohistochemical staining for c-FOS in the cochlea shows a small area of optical stimulation, which occurs directly opposite to the optical fiber. Additionally, masking data indicate that the laser can stimulate a small population of cells similar to an acoustic toneburst. Smaller populations of stimulated cells could reduce the amount of overlap in stimulation fields and allow more stimulation contacts in a neuroprothesis.

Paper Details

Date Published: 22 February 2006
PDF: 8 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60781P (22 February 2006); doi: 10.1117/12.659743
Show Author Affiliations
Agnella D. Izzo, Northwestern Univ. (United States)
Jyoti Pathria, Feinberg Medical School, Northwestern Univ. (United States)
Eul Suh, Feinberg Medical School, Northwestern Univ. (United States)
Joseph T. Walsh, Northwestern Univ. (United States)
Donna S. Whitlon, Feinberg Medical School, Northwestern Univ. (United States)
Northwestern Univ. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Claus-Peter Richter, Feinberg Medical School, Northwestern Univ. (United States)


Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory; Nikiforos Kollias; Reza S. Malek; Michael D. Lucroy; Henry Hirschberg; Brian Jet-Fei Wong; Eugene A. Trowers; Werner T.W. de Riese; Justus F. R. Ilgner; Steen J. Madsen; Lloyd P. Tate; Haishan Zeng; Guillermo J. Tearney; Bernard Choi, Editor(s)

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