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Proceedings Paper

3D reconstructions from spherically averaged Fourier transform magnitude and solution x-ray scattering experiments
Author(s): Youngha Hwang; Peter C. Doerschuk
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Paper Abstract

Measuring the scattering of a beam of x-rays off a solution of identical particles gives data that is the spherically averaged magnitude of the Fourier transform of the electron number density in the particle. Although the 1-D data provides only limited information for a 3-D reconstruction of the particle, this approach is still attractive because it does not require that the particle be crystallized for x-ray crystallography or frozen for cryo electron microscopy. We describe ongoing work using two mathematical models of the particle, a piecewise constant model and an orthonormal expansion model, and a variety of specialized optimization tools to determine the 3-D reconstruction of the particle from a weighted nonlinear least squares problem.

Paper Details

Date Published: 2 February 2006
PDF: 6 pages
Proc. SPIE 6065, Computational Imaging IV, 60650G (2 February 2006); doi: 10.1117/12.659446
Show Author Affiliations
Youngha Hwang, Purdue Univ. (United States)
Peter C. Doerschuk, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 6065:
Computational Imaging IV
Charles A. Bouman; Eric L. Miller; Ilya Pollak, Editor(s)

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