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Proceedings Paper

Mechanical extension implants for short-bowel syndrome
Author(s): Jonathan Luntz; Diann Brei; Daniel Teitelbaum; Ariel Spencer
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Paper Abstract

Short-bowel syndrome (SBS) is a rare, potentially lethal medical condition where the small intestine is far shorter than required for proper nutrient absorption. Current treatment, including nutritional, hormone-based, and surgical modification, have limited success resulting in 30% to 50% mortality rates. Recent advances in mechanotransduction, stressing the bowel to induce growth, show great promise; but for successful clinical use, more sophisticated devices that can be implanted are required. This paper presents two novel devices that are capable of the long-term gentle stressing. A prototype of each device was designed to fit inside a short section of bowel and slowly extend, allowing the bowel section to grow approximately double its initial length. The first device achieves this through a dual concentric hydraulic piston that generated almost 2-fold growth of a pig small intestine. For a fully implantable extender, a second device was developed based upon a shape memory alloy actuated linear ratchet. The proof-of-concept prototype demonstrated significant force generation and almost double extension when tested on the benchtop and inside an ex-vivo section of pig bowel. This work provides the first steps in the development of an implantable extender for treatment of SBS.

Paper Details

Date Published: 5 April 2006
PDF: 11 pages
Proc. SPIE 6173, Smart Structures and Materials 2006: Smart Structures and Integrated Systems, 617309 (5 April 2006); doi: 10.1117/12.659112
Show Author Affiliations
Jonathan Luntz, Univ. of Michigan (United States)
Diann Brei, Univ. of Michigan (United States)
Daniel Teitelbaum, Univ. of Michigan (United States)
Ariel Spencer, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 6173:
Smart Structures and Materials 2006: Smart Structures and Integrated Systems
Yuji Matsuzaki, Editor(s)

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