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Proceedings Paper

Biomolecules as nanomaterials: interface characterization for sensor development
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Paper Abstract

Extensive research is underway to understand and exploit the interface between biological materials and integrated systems Today, "nanotechnology" can be defined as a group of emerging technologies in which the structure of matter is controlled at the nanometer scale, the scale of small numbers of atoms, to produce novel materials and devices having useful and unique properties. An ideal biological candidate for use in nanoscale devices is the microtubule, an essential component of the eukaryotic cytoskeleton, which, unlike most proteins, has been shown to be electrically conductive. Due to the presence of an intrinsic dipole in the protein polymer, RF reflectance spectroscopy was chosen as an interrogation method. RF reflectance spectroscopy measures the electrical response of a sample in response to sinusoidally alternating currents as a function of frequency By interrogating the protein electrically, we are able to detect the polymerization state of the system, track any associated conductivity changes, and monitor binding of microtubule-associated proteins. We demonstrate manipulation of the microtubule system through the use of low-frequency electric fields, and discuss implications for sensor development.

Paper Details

Date Published: 31 March 2006
PDF: 12 pages
Proc. SPIE 6172, Smart Structures and Materials 2006: Smart Electronics, MEMS, BioMEMS, and Nanotechnology, 617206 (31 March 2006); doi: 10.1117/12.658771
Show Author Affiliations
Gregory Goddard, Los Alamos National Lab. (United States)
Ctr. for Integrated Nanotechnologies (United States)
Athanor, Inc. (United States)
Jennifer E. Whittier, Los Alamos National Lab. (United States)
Ctr. for Integrated Nanotechnologies (United States)
Athanor, Inc. (United States)


Published in SPIE Proceedings Vol. 6172:
Smart Structures and Materials 2006: Smart Electronics, MEMS, BioMEMS, and Nanotechnology
Vijay K. Varadan, Editor(s)

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