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Proceedings Paper

Multiwell cell culture plate format with integrated microfluidic perfusion system
Author(s): Karel Domansky; Walker Inman; Jim Serdy; Linda G. Griffith
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Paper Abstract

A new cell culture analog has been developed. It is based on the standard multiwell cell culture plate format but it provides perfused three-dimensional cell culture capability. The new capability is achieved by integrating microfluidic valves and pumps into the plate. The system provides a means to conduct high throughput assays for target validation and predictive toxicology in the drug discovery and development process. It can be also used for evaluation of long-term exposure to drugs or environmental agents or as a model to study viral hepatitis, cancer metastasis, and other diseases and pathological conditions.

Paper Details

Date Published: 23 January 2006
PDF: 8 pages
Proc. SPIE 6112, Microfluidics, BioMEMS, and Medical Microsystems IV, 61120F (23 January 2006); doi: 10.1117/12.655686
Show Author Affiliations
Karel Domansky, MIT (United States)
Walker Inman, MIT (United States)
Jim Serdy, MIT (United States)
Linda G. Griffith, MIT (United States)


Published in SPIE Proceedings Vol. 6112:
Microfluidics, BioMEMS, and Medical Microsystems IV
Ian Papautsky; Wanjun Wang, Editor(s)

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