Share Email Print
cover

Proceedings Paper

Quantification for contrast-enhanced digital breast tomosynthesis
Author(s): Ann-Katherine Carton; Jingjing Li; Michael Albert; Sara Chen; Andrew D. A. Maidment
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Digital breast tomosynthesis (DBT) is a tomographic technique in which individual slices through the breast are reconstructed from x-ray projection images acquired over a limited angular range. In contrast-enhanced DBT (CE-DBT) functional information can be observed by administration of an x-ray contrast agent. We have investigated the technical requirements necessary to quantitatively analyze CE-DBT exams. Using a simplified physiological model, a maximum aerial concentration of approximately 2.2 mg iodine/cm2 in a 0.5 cm thick breast lesion is expected when administering 70 ml of 320 mg iodine/ml Visipaque-320®. This corresponds to a small change in x-ray transmission; up to 5% for a 4 cm thick compressed breast. We have modeled CE-DBT acquisition by simulating Rh target x-ray spectra from 40 to 49 kV. Comparison of attenuation data of our simulated and measured spectra were found to agree well. We investigated the effect of scatter, patient motion and temporal stability of the detector on quantifying iodine uptake. These parameters were evaluated by means of experiments and theoretical modeling.

Paper Details

Date Published: 2 March 2006
PDF: 11 pages
Proc. SPIE 6142, Medical Imaging 2006: Physics of Medical Imaging, 61420D (2 March 2006); doi: 10.1117/12.654682
Show Author Affiliations
Ann-Katherine Carton, Hospital of the Univ. of Pennsylvania (United States)
Jingjing Li, Hospital of the Univ. of Pennsylvania (United States)
Michael Albert, Hospital of the Univ. of Pennsylvania (United States)
Sara Chen, Hospital of the Univ. of Pennsylvania (United States)
Andrew D. A. Maidment, Hospital of the Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 6142:
Medical Imaging 2006: Physics of Medical Imaging
Michael J. Flynn; Jiang Hsieh, Editor(s)

© SPIE. Terms of Use
Back to Top