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Proceedings Paper

Precise imaging of small animals using a dual-head microPET scanner
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Paper Abstract

We believe that small-animal positron emission tomography (μPET) can play an important role in phenotyping and drug screening. For such applications, imaging throughput becomes an important issue because one needs to image a considerable number of subjects in a study. Toward enabling high-throughput μPET imaging, we are developing a prototype that consists of two large-area, high-performance flat detectors. These detectors are placed opposed to each other with a small spacing for providing large detection solid angle and detection sensitive volume. The resulting scanner geometry produces data having missing views and projection truncations, therefore posing a particular challenge in reconstruction. In this paper, we developed a new iterative reconstruction method that addresses this challenge. By using 2D simulated data, we find that this new method can accurately reconstruct an extended detection volume of the prototype. Because our prototype shares the same configuration with positron emission mammography (PEM), the new reconstruction method is also applicable for PEM reconstruction.

Paper Details

Date Published: 13 March 2006
PDF: 6 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 614303 (13 March 2006); doi: 10.1117/12.654528
Show Author Affiliations
Chien-Min Kao, The Univ. of Chicago (United States)
Emil Sidky, The Univ. of Chicago (United States)
Yun Dong, Illinois Institute of Technology (United States)
Xiaochuan Pan, The Univ. of Chicago (United States)


Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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