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Proceedings Paper

Towards patient-specific modeling I: hemodynamics in a growing aneurysm
Author(s): C. Alberto Figueroa; Seungik Baek; Irene E. Vignon-Clementel; Jay D. Humphrey; Charles A. Taylor
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Paper Abstract

Modeling aneurysm growth using stress-mediated growth laws requires accurate knowledge of the hemodynamic stresses and strains acting on the aneurysm wall due to the internal blood flow and the external tissue support. Therefore, solving the coupled problem of blood flow and vessel wall deformation represents a critical step in the evaluation of these hemodynamic stresses, but for large, patient-specific models of the vasculature one that is computationally expensive. In this work, we present the application of a new formulation, the Coupled Momentum Method for Fluid-Solid Interaction (CMM-FSI), to compute blood flow and vessel wall deformation under realistic ranges of pressures for large patient-specific models of the cerebro-vasculature. The method couples the equations of the deformation of the vessel wall at the variational level as a boundary condition for the fluid domain. We consider a strong coupling of the degrees-of-freedom of the fluid interface and the wall domains. The effect of the vessel wall boundary is therefore added in a monolithic way to the fluid equations, resulting in a remarkably robust and computationally-efficient scheme. The method is applied to patient-specific model of the Circle of Willis featuring a saccular aneurysm, using resistance outflow boundary conditions. The wall normal and shear stresses resulting from the simulation can then be used as the hemodynamic forces mediating the aneurysm wall adaptation in the algorithm shown in the second part of this work.

Paper Details

Date Published: 13 March 2006
PDF: 11 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61430K (13 March 2006); doi: 10.1117/12.653948
Show Author Affiliations
C. Alberto Figueroa, Stanford Univ. (United States)
Seungik Baek, Texas A&M Univ. (United States)
Irene E. Vignon-Clementel, Stanford Univ. (United States)
Jay D. Humphrey, Texas A&M Univ. (United States)
Charles A. Taylor, Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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