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Proceedings Paper

Uterine fibroid segmentation and volume measurement on MRI
Author(s): Jianhua Yao; David Chen; Wenzhu Lu; Ahalya Premkumar
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Paper Abstract

Uterine leiomyomas are the most common pelvic tumors in females. The efficacy of medical treatment is gauged by shrinkage of the size of these tumors. In this paper, we present a method to robustly segment the fibroids on MRI and accurately measure the 3D volume. Our method is based on a combination of fast marching level set and Laplacian level set. With a seed point placed inside the fibroid region, a fast marching level set is first employed to obtain a rough segmentation, followed by a Laplacian level set to refine the segmentation. We devised a scheme to automatically determine the parameters for the level set function and the sigmoid function based on pixel statistics around the seed point. The segmentation is conducted on three concurrent views (axial, coronal and sagittal), and a combined volume measurement is computed to obtain a more reliable measurement. We carried out extensive tests on 13 patients, 25 MRI studies and 133 fibroids. The segmentation result was validated against manual segmentation defined by experts. The average segmentation sensitivity (true positive fraction) among all fibroids was 84.6%, and the average segmentation specificity (1-false positive fraction) was 84.3%.

Paper Details

Date Published: 13 March 2006
PDF: 10 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 614322 (13 March 2006); doi: 10.1117/12.653856
Show Author Affiliations
Jianhua Yao, National Institutes of Health (United States)
David Chen, National Institutes of Health (United States)
Wenzhu Lu, Towson Univ. (United States)
Ahalya Premkumar, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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