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Proceedings Paper

The brain perfusion imaging in predicting the cerebral ischemia using vessel-around method
Author(s): Chung-Il Ahn; Kyo Bum Ku; Dong Kyun Jeong; Sang Wook Cho; Bo hyung Kim; Yeong Gil Shin
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Paper Abstract

Perfusion CT has been successfully used as a functional imaging technique for diagnosis of patients with ischemic stroke. Numerous researchers have investigated to what extent Perfusion CT can be used for the quantitative assessment of cerebral ischemia and to rapidly obtain comprehensive information regarding the extent of ischemic damage in acute stroke patients. The aim of this study is to show the cerebral flow imaging of the vessel and tissue in human brain and to propose an alternative approach to obtain the brain perfusion mapping. During the first pass of the contrast bolus through the brain, vasculature, local concentrations of iodine are simply reflected by changes in the attenuation values measured with CT. The measured attenuation values can be clarified to Vessel Candidate, Vessel-Around, Non Vessel, Non-perfusion Area using vessel around model and be mapped into the cerebral imaging proposed. The threshold for clarifying the measured attenuation values was determined by the analyzing the characteristics of values and modified as to the acquisition dataset. In order to restrict calculations to actual brain tissue the first pre-contrast scan is segmented using contour finding of the skull bone and CT value based exclusion of cerebro spinal fluid space (CSF). The defined vessel-around model was used to show the cerebral flow imaging and to specify the area of markedly reduced perfusion with loss of function of still viable neurons. We calculated the perfusion parameters using the GVF and the cerebral imaging with the vessel candidate and analyzed the mapping values using the TAC. To validate the mapping values, using many clinical cases, the Mapping results and the perfusion parameters was compared and validated by the physicians and medical staff. The results showed that cerebral imaging using the vessel-around model is the same reliable map as the perfusion imaging using the GVF. The proposed vessel-around model can be successfully applied to cerebral imaging for brain perfusion studies. Using the vessel-around model, the proposed cerebral imaging shows the reliable and rapid results of human brain perfusion. Moreover the vessel-around approach was found to be comprehensive and easy-to-interpret by physicians and medical staff, hence we conclude that our proposed vessel-around technique can be used for brain perfusion mapping.

Paper Details

Date Published:
PDF: 8 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431W; doi: 10.1117/12.653227
Show Author Affiliations
Chung-Il Ahn, INFINITT Co., Ltd (South Korea)
Kyo Bum Ku, INFINITT Co., Ltd (South Korea)
Dong Kyun Jeong, INFINITT Co., Ltd (South Korea)
Sang Wook Cho, INFINITT Co., Ltd (South Korea)
Bo hyung Kim, INFINITT Co., Ltd (South Korea)
Yeong Gil Shin, INFINITT, Co., Ltd. (South Korea)
Seoul National Univ. (South Korea)

Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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