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Proceedings Paper

MRI-relaxometry BMD-measurements using conventional phase symmetrized rapid increased flip spin echo (PRISE) and standard gradient echo (GE)
Author(s): Morteza Bakhtiary; Nader Riyahi-Alam; Mohammad-Ali Oghabian; Ali Ghasemzadeh; Hossein Ghanaati; Saeed Sarkar; Bagher Larijani; Zohreh Hamidy-Abarghouie; Naser Shakery
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Paper Abstract

The aim of this study was to use conventional MRI protocols for BMD measurements using MRIRelaxometry. Cortical and trabecular bone separation cannot be performed in DEXA, so the results might lead to erroneous interpretation of BMD values. One of the new special protocols is Gradient-Echo Sampling of Free-Induction-Decay and Echo (GESFIDE) used on General-Electric systems for deriving R2(=1/T2), R2*(=1/T2*) and R2'(=R2*-R2) in several application. GESFIDE give 8-16 echoes (images) in single scan. It can be used only in system with high slew rate (22 mT/m.s or greater) due to several high slew rate gradients with high amplitudes in small periods. This study was performed by 1.5T MRI system (Picker Vista-Q800) with slew rate of 13 mT/m.s, SNR phantom (1.25gr/l CuSO4, with T2=200ms for calibration), a body RF-Coil, 7 normal, 7 osteopenia, 7 osteoporosis volunteers and Lunar DEXA system (DPX-MD). To determine R2* and R2, several Gradient-Echo(GE) and Spin-Echo(SE) protocols with different TE/TR were analyzed and compared with GESFIDE protocol’s gradients. Also calculated R2 and R2* using SNR phantom were compared with desired amounts. Then in coronal section of femoral-neck, relaxation rates were compared with BMD. Therefore, for R2* measurement standard-GE protocol with TE=13.42/18/26.8ms, TR=800ms and ST=8mm [CV(R2*)=2.96%] and for R2 measurement PRISE protocol with TE=36/54/63/72ms, TR=800ms and ST=8mm [CV(R2)=3%] were selected. R2* and R2' showed a significant positive correlation with BMD(r=0.62, p<0.05). Finally, in accordance with DEXA values, the results showed that PRISE and standard GE are proper protocols for BMDmeasurements in femoral-neck in spite of GESFIDE.

Paper Details

Date Published:
PDF: 8 pages
Proc. SPIE 6142, Medical Imaging 2006: Physics of Medical Imaging, 61423R; doi: 10.1117/12.652694
Show Author Affiliations
Morteza Bakhtiary, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Nader Riyahi-Alam, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Mohammad-Ali Oghabian, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Ali Ghasemzadeh, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Hossein Ghanaati, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Saeed Sarkar, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Bagher Larijani, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Zohreh Hamidy-Abarghouie, School of Medicine/Tehran Univ. of Medical Sciences (Iran)
Naser Shakery, School of Medicine/Tehran Univ. of Medical Sciences (Iran)


Published in SPIE Proceedings Vol. 6142:
Medical Imaging 2006: Physics of Medical Imaging
Michael J. Flynn; Jiang Hsieh, Editor(s)

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