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Proceedings Paper

An ISO-surface folding analysis method applied to premature neonatal brain development
Author(s): Claudia E. Rodriguez-Carranza; Francois Rousseau; Bistra Iordanova; Orit Glenn; Daniel Vigneron; James Barkovich; Colin Studholme
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Paper Abstract

In this paper we describe the application of folding measures to tracking in vivo cortical brain development in premature neonatal brain anatomy. The outer gray matter and the gray-white matter interface surfaces were extracted from semi-interactively segmented high-resolution T1 MRI data. Nine curvature- and geometric descriptor-based folding measures were applied to six premature infants, aged 28-37 weeks, using a direct voxelwise iso-surface representation. We have shown that using such an approach it is feasible to extract meaningful surfaces of adequate quality from typical clinically acquired neonatal MRI data. We have shown that most of the folding measures, including a new proposed measure, are sensitive to changes in age and therefore applicable in developing a model that tracks development in premature infants. For the first time gyrification measures have been computed on the gray-white matter interface and on cases whose age is representative of a period of intense brain development.

Paper Details

Date Published: 10 March 2006
PDF: 11 pages
Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61441K (10 March 2006); doi: 10.1117/12.652516
Show Author Affiliations
Claudia E. Rodriguez-Carranza, Northern California Institute for Research and Education, VAMC (United States)
Francois Rousseau, Northern California Institute for Research and Education, VAMC (United States)
Bistra Iordanova, Northern California Institute for Research and Education, VAMC (United States)
Orit Glenn, Univ. of California, San Francisco (United States)
Daniel Vigneron, Univ. of California, San Francisco (United States)
James Barkovich, Univ. of California, San Francisco (United States)
Colin Studholme, Univ. of California, San Francisco (United States)
Northern California Institute for Research and Education, VAMC (United States)


Published in SPIE Proceedings Vol. 6144:
Medical Imaging 2006: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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