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Proceedings Paper

Functional and behavioral metrics for evaluating laser retinal damage
Author(s): Cheryl D. DiCarlo; Gary L. Martinsen; Thomas Garza; Andres Grado; Juan Morin; Araceli Brown; David Stolarski; Clarence Cain
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Paper Abstract

The use of lasers by both the military and civilian community is rapidly expanding. Thus, the potential for and severity of laser eye injury and retinal damage is increasing. Sensitive and accurate methods to evaluate and follow laser retinal damage are needed. The multifocal electroretinogram (mfERG) has the potential to meet these criteria. In this study, the mfERG was used to evaluate changes to retinal function following laser exposure. Landolt C contrast acuity was also measured in the six behaviorally trained Rhesus monkeys. The monkeys then received Nd:YAG laser lesions (1064 nm, 9 ns pulse width) in each eye. One eye received a single foveal lesion of approximately 0.13 mJ total intraocular exposure (TIE) and the other received six parafoveal lesions which varied in TIE from 0.13 to 4 mJ. mfERGs and behavioral data were collected both pre- and post-exposure. mfERGs were recorded using stimuli that contained 103, 241, and 509 hexagons. Landolt C contrast acuity was measured with five sizes of Landolt C (0.33 to 11.15 cycles/degree) of varying contrast. mfERG response densities were sensitive to the functional retinal changes caused by the laser insult. In general, larger lesions showed greater mfERG abnormalities than smaller laser lesions. Deficits in contrast acuity were found to be more severe in the eyes with foveal injuries. Although the mfERG and contrast acuity assess different areas of the visual system, both are sensitive to laser-induced retinal damage and may be complementary tests for laser eye injury triage.

Paper Details

Date Published: 22 February 2006
PDF: 11 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607837 (22 February 2006); doi: 10.1117/12.652232
Show Author Affiliations
Cheryl D. DiCarlo, U.S. Army Institute of Surgical Research (United States)
Gary L. Martinsen, Air Force Research Lab. (United States)
Thomas Garza, TRUE Research Foundation (United States)
Andres Grado, U.S. Army Medical Research Detachment (United States)
Juan Morin, T.R.U.E Research Foundation (United States)
Araceli Brown, Walter Reed Army Institute of Research (United States)
David Stolarski, Northrop Grumman Information Technology (United States)
Clarence Cain, Northrop Grumman Information Technology (United States)


Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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