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Proceedings Paper

Impact of noise-on-image reconstruction for diffuse optical tomography
Author(s): Tim Nielsen; Thomas Köhler
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Paper Abstract

Diffuse optical tomography (DOT) uses the transmission of near-infrared light through tissue to image absorption and scattering. Especially for mammography applications DOT might become of clinical use. In this work we present simulation results on the influence of noise on the detectability of lesions for the Philips mammoscope system. Noise can have a significant impact on the image quality. It can prevent the detection of even high contrast lesions. The influence of noise can be reduced by a proper treatment in the reconstruction algorithm. But it changes also the effective sampling pattern of the imaging system if noisy data are not used (or used with a lower weight). In the case of this optical tomography system this means that lesions are only detectable up to a certain depth. This depth depends on where the signal power gets close to the constant noise floor, and on the volume and contrast of the lesion. Our simulation results show that the detection of lesions with 10 mm diameter and 100% absorption contrast should be possible with the mammoscope system, even in the worst case where the lesion is located in the center of the breast.

Paper Details

Date Published: 2 March 2006
PDF: 8 pages
Proc. SPIE 6142, Medical Imaging 2006: Physics of Medical Imaging, 61420M (2 March 2006); doi: 10.1117/12.651297
Show Author Affiliations
Tim Nielsen, Philips Research Labs. (Germany)
Thomas Köhler, Philips Research Labs. (Germany)


Published in SPIE Proceedings Vol. 6142:
Medical Imaging 2006: Physics of Medical Imaging
Michael J. Flynn; Jiang Hsieh, Editor(s)

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