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Proceedings Paper

Multimode spectroscopy for the in vivo assessment of post-inflammatory pigmentation: preliminary observations
Author(s): Jianhua Zhao; Hana Alkhayat; Ahmad Al Robaee; Haishan Zeng; David I. McLean; Harvey Lui
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Paper Abstract

Although post-inflammatory pigmentation (PIH) is a common acquired skin disorder, however, its mechanism still remains unclear. In this paper, multimode optical spectroscopic techniques including diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy have been used to probe the morphologic and biochemical changes associated with PIH. Both pigmented skin and the adjacent normal skin were measured for paired analysis. Distinctive spectral features were observed which may provide the potentials for identifying the mechanism of PIH. The diffuse reflectance spectrum was also converted into the CIE standard L*a*b* color system. The melanin and the hemoglobin content in the PIH were quantitatively derived from the diffusive reflectance spectrum using the Stamatas-Kollias algorithm. It was found that PIH always has a lower value in L* and more melanin and hemoglobin content which is consistent with clinical appearance of dark skin as perceived by the human eye.

Paper Details

Date Published: 22 February 2006
PDF: 5 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607809 (22 February 2006); doi: 10.1117/12.650200
Show Author Affiliations
Jianhua Zhao, BC Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
Hana Alkhayat, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
Ahmad Al Robaee, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
Haishan Zeng, BC Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
David I. McLean, BC Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
Harvey Lui, BC Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)


Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory; Nikiforos Kollias; Reza S. Malek; Michael D. Lucroy; Henry Hirschberg; Brian Jet-Fei Wong; Eugene A. Trowers; Werner T.W. de Riese; Justus F. R. Ilgner; Steen J. Madsen; Lloyd P. Tate; Haishan Zeng; Guillermo J. Tearney; Bernard Choi, Editor(s)

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