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Proceedings Paper

Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice
Author(s): Baowei Fei; Hesheng Wang; Raymond F. Muzic; Chris A. Flask; Denise Feyes; David L. Wilson; Jeffrey L. Duerk; Nancy L. Oleinick
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Paper Abstract

We are investigating imaging techniques to study the tumor response to photodynamic therapy (PDT). PET can provide physiological and functional information. High-resolution MRI can provide anatomical and morphological changes. Image registration can combine MRI and PET images for improved tumor monitoring. In this study, we acquired high-resolution MRI and microPET [18F]fluorodeoxyglucose (FDG) images from C3H mice with RIF-1 tumors that were treated with Pc 4-based PDT. For tumor registration, we developed a finite element model (FEM)-based deformable registration scheme. To assess the registration quality, we performed slice by slice review of both image volumes, computed the volume overlap ratios, and visualized both volumes in color overlay. The mean volume overlap ratios for tumors were 94.7% after registration. Registration of high-resolution MRI and microPET images combines anatomical and functional information of the tumors and provides a useful tool for evaluating photodynamic therapy.

Paper Details

Date Published: 13 March 2006
PDF: 10 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61433I (13 March 2006); doi: 10.1117/12.649531
Show Author Affiliations
Baowei Fei, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)
Hesheng Wang, Case Western Reserve Univ. (United States)
Raymond F. Muzic, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)
Chris A. Flask, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)
Denise Feyes, Case Western Reserve Univ. (United States)
David L. Wilson, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)
Jeffrey L. Duerk, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)
Nancy L. Oleinick, Case Western Reserve Univ. (United States)


Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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