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Proceedings Paper

Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT
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Paper Abstract

Spectral-Domain Optical Coherence Tomography (SDOCT) allows for in-vivo video-rate investigation of biomedical tissue depth structure intended for non-invasive optical diagnostics. It has been suggested that OCT can be used for di-agnosis of glaucoma by measuring the thickness of the Retinal Nerve Fiber Layer (RNLF). We present an automated method for determining the RNFL thickness from a 3-D dataset based on edge detection using a deformable spline algo-rithm. The RNFL thickness map is combined with an integrated reflectance map and retinal cross-sectional images to provide the ophthalmologist with a familiar image for interpreting the OCT data. The video-rate capabilities of our SDOCT system allow for mapping the true retinal topography since motion artifacts are significantly reduced as com-pared to slower time-domain systems. Combined with Doppler Velocimetry, SDOCT also provides information on retinal blood flow dynamics. We analyzed the pulsatile nature of the bidirectional flow dynamics in an artery-vein pair for a healthy volunteer at different locations and for different blood vessel diameters. The Doppler phase shift is determined as the phase difference at the same point of adjacent depth profiles, and is integrated over the area delimited by two circles corresponding to the blood vessels location. Its temporal evolution clearly shows the blood flow pulsatile nature, the cardiac cycle, in both artery and vein. The artery is identified as having a stronger variation of the integrated phase shift. We observe that artery pulsation is always easily detectable, while vein pulsation seems to depend on the veins diameter.

Paper Details

Date Published: 20 February 2006
PDF: 7 pages
Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 607909 (20 February 2006); doi: 10.1117/12.649095
Show Author Affiliations
Mircea Mujat, Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Raymond C. Chan, Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Barry Cense, Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Mark Pierce, Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Hyle Park, Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Chulmin Joo, Massachusetts General Hospital (United States)
Massachusetts Institute of Technology (United States)
Teresa C. Chen, Harvard Medical School (United States)
Massachusetts Eye and Ear Infirmary (United States)
Johannes F. de Boer, Harvard Medical School (United States)
Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 6079:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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