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Proceedings Paper

Burn depth determination using high-speed polarization-sensitive Mueller optical coherence tomography with continuous polarization modulation
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Paper Abstract

National Health Interview Survey (NHIS) estimates more than 1.1 million burn injuries per year in the United States, with nearly 15,000 fatalities from wounds and related complications. An imaging modality capable of evaluating burn depths non-invasively is the polarization-sensitive optical coherence tomography. We report on the use of a high-speed, fiber-based Mueller-matrix OCT system with continuous source-polarization modulation for burn depth evaluation. The new system is capable of imaging at near video-quality frame rates (8 frames per second) with resolution of 10 μm in biological tissue (index of refraction: 1.4) and sensitivity of 78 dB. The sample arm optics is integrated in a hand-held probe simplifying the in vivo experiments. The applicability of the system for burn depth determination is demonstrated using biological samples of porcine tendon and porcine skin. The results show an improved imaging depth (1 mm in tendon) and a clear localization of the thermally damaged region. The burnt area determined from OCT images compares well with the histology, thus proving the system's potential for burn depth determination.

Paper Details

Date Published: 20 February 2006
PDF: 5 pages
Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 60792B (20 February 2006); doi: 10.1117/12.649024
Show Author Affiliations
Miloš Todorović, Texas A&M Univ. (United States)
Jun Ai, Texas A&M Univ. (United States)
David Pereda Cubian, Texas A&M Univ. (United States)
George Stoica, Texas A&M Univ. (United States)
Lihong Wang, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 6079:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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