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Proceedings Paper

Injection molded microfluidic devices for biological sample separation and detection
Author(s): Alfredo M. Morales; Blake A. Simmons; Thomas I. Wallow; K. Jeffery Campbell; Seethambal S. Mani; Brita Mittal; Robert W. Crocker; Eric B. Cummings; Rafael V. Davalos; Linda A. Domeier; Marion C. Hunter; Karen L. Krafcik; Gregory J. McGraw; Bruce P. Mosier; Shane M. Sickafoose
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Paper Abstract

We are developing a variety of microsystems for the separation and detection of biological samples. At the heart of these systems, inexpensive polymer microfluidic chips carry out sample preparation and analysis. Fabrication of polymer microfluidic chips involves the creation of a master in etched silicon or glass; plating of the master to produce a nickel stamp; large lot chip replication by injection molding; precision chip sealing; and chemical modification of channel surfaces. Separation chips rely on insulator-based dielectrophoresis for the separation of biological particles. Detection chips carry out capillary electrophoresis to detect fluorescent tags that identify specific biological samples. Since the performance and reliability of these microfluidic chips are very sensitive to fluidic impedance, electromagnetic flux, and zeta potential, the microchannel dimensions, shape, and surface chemistry have to be tightly controlled during chip fabrication and use. This paper will present an overview of chip design, fabrication, and testing. Dimensional metrology data, surface chemistry characterization, and chip performance data will be discussed in detail.

Paper Details

Date Published: 23 January 2006
PDF: 11 pages
Proc. SPIE 6109, Micromachining and Microfabrication Process Technology XI, 610901 (23 January 2006); doi: 10.1117/12.648135
Show Author Affiliations
Alfredo M. Morales, Sandia National Labs. (United States)
Blake A. Simmons, Sandia National Labs. (United States)
Thomas I. Wallow, Advanced Micro Devices (United States)
K. Jeffery Campbell, Sandia National Labs. (United States)
Seethambal S. Mani, Sandia National Labs. (United States)
Brita Mittal, Sandia National Labs. (United States)
Robert W. Crocker, Sandia National Labs. (United States)
Eric B. Cummings, Sandia National Labs. (United States)
Rafael V. Davalos, Sandia National Labs. (United States)
Linda A. Domeier, Sandia National Labs. (United States)
Marion C. Hunter, Sandia National Labs. (United States)
Karen L. Krafcik, Sandia National Labs. (United States)
Gregory J. McGraw, Sandia National Labs. (United States)
Bruce P. Mosier, Sandia National Labs. (United States)
Shane M. Sickafoose, Sandia National Labs. (United States)

Published in SPIE Proceedings Vol. 6109:
Micromachining and Microfabrication Process Technology XI
Mary-Ann Maher; Harold D. Stewart; Jung-Chih Chiao, Editor(s)

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