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Proceedings Paper

Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy
Author(s): Suresh K. Pandey; Yihui Chen; Robert H. Zawada; Allan Oseroff; Ravindra K. Pandey
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Paper Abstract

HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λex: 780 nm, λem: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.

Paper Details

Date Published: 6 March 2006
PDF: 7 pages
Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613905 (6 March 2006); doi: 10.1117/12.647866
Show Author Affiliations
Suresh K. Pandey, Roswell Park Cancer Institute (United States)
Yihui Chen, Roswell Park Cancer Institute (United States)
Robert H. Zawada, Roswell Park Cancer Institute (United States)
Allan Oseroff, Roswell Park Cancer Institute (United States)
Ravindra K. Pandey, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 6139:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
David Kessel, Editor(s)

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