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Proceedings Paper

OCT visualization of mucosal radiation damage in patients with head and neck cancer: pilot study
Author(s): Natalia Gladkova M.D.; Anna Maslennikova; Irina Balalaeva; Yulia Vyseltseva; Natalia Kornoukhova; Roman Larin; Anna Terentieva; Nina Khomutinnikova; Yulia Fomina; Vladislav Kamensky; Grigory Gelikonov; Felix Feldchtein
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Paper Abstract

We present the results in optical coherence tomography (OCT) visualization of structural changes in human oral cavity and pharyngeal mucosa for 14 patients in the process of radiation and chemoradiation therapy. Typical mucosal changes are seen as a decrease in the tissue layer contrast progressing to a complete contrast loss as severe mucosal damage occurs. Similar evolution in OCT images was observed for all patients. OCT changes can be seen prior to visual mucosal changes and increased as more mucosal damage occurs. Moreover, OCT was able to obtain information on the specific features of the patient response depending on the irradiation method and the individual radiosensitivity.

Paper Details

Date Published: 22 February 2006
PDF: 8 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60781J (22 February 2006); doi: 10.1117/12.647601
Show Author Affiliations
Natalia Gladkova M.D., Nizhny Novgorod Medical Academy (Russia)
Anna Maslennikova, Nizhny Novgorod Medical Academy (Russia)
Irina Balalaeva, Institute of Applied Physics (Russia)
Yulia Vyseltseva, Nizhny Novgorod Medical Academy (Russia)
Natalia Kornoukhova, Nizhny Novgorod Medical Academy (Russia)
Roman Larin, Nizhny Novgorod Medical Academy (Russia)
Anna Terentieva, Nizhny Novgorod Medical Academy (Russia)
Nina Khomutinnikova, Nizhny Novgorod Medical Academy (Russia)
Yulia Fomina, Nizhny Novgorod Medical Academy (Russia)
Vladislav Kamensky, Institute of Applied Physics (Russia)
Grigory Gelikonov, Institute of Applied Physics (Russia)
Felix Feldchtein, Institute of Applied Physics (Russia)
Imalux Corp. (United States)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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