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Proceedings Paper

Precision targeting with a tracking adaptive optics scanning laser ophthalmoscope
Author(s): Daniel X. Hammer; R. Daniel Ferguson; Chad E. Bigelow; Nicusor V. Iftimia; Teoman E. Ustun; Gary D. Noojin; David J. Stolarski; Harvey M. Hodnett; Michelle L. Imholte; Semih S. Kumru; Michelle N. McCall; Cynthia A. Toth; Benjamin A. Rockwell
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Paper Abstract

Precise targeting of retinal structures including retinal pigment epithelial cells, feeder vessels, ganglion cells, photoreceptors, and other cells important for light transduction may enable earlier disease intervention with laser therapies and advanced methods for vision studies. A novel imaging system based upon scanning laser ophthalmoscopy (SLO) with adaptive optics (AO) and active image stabilization was designed, developed, and tested in humans and animals. An additional port allows delivery of aberration-corrected therapeutic/stimulus laser sources. The system design includes simultaneous presentation of non-AO, wide-field (~40 deg) and AO, high-magnification (1-2 deg) retinal scans easily positioned anywhere on the retina in a drag-and-drop manner. The AO optical design achieves an error of <0.45 waves (at 800 nm) over ±6 deg on the retina. A MEMS-based deformable mirror (Boston Micromachines Inc.) is used for wave-front correction. The third generation retinal tracking system achieves a bandwidth of greater than 1 kHz allowing acquisition of stabilized AO images with an accuracy of ~10 μm. Normal adult human volunteers and animals with previously-placed lesions (cynomolgus monkeys) were tested to optimize the tracking instrumentation and to characterize AO imaging performance. Ultrafast laser pulses were delivered to monkeys to characterize the ability to precisely place lesions and stimulus beams. Other advanced features such as real-time image averaging, automatic highresolution mosaic generation, and automatic blink detection and tracking re-lock were also tested. The system has the potential to become an important tool to clinicians and researchers for early detection and treatment of retinal diseases.

Paper Details

Date Published: 7 March 2006
PDF: 10 pages
Proc. SPIE 6138, Ophthalmic Technologies XVI, 613811 (7 March 2006); doi: 10.1117/12.647477
Show Author Affiliations
Daniel X. Hammer, Physical Sciences Inc. (United States)
R. Daniel Ferguson, Physical Sciences Inc. (United States)
Chad E. Bigelow, Physical Sciences Inc. (United States)
Nicusor V. Iftimia, Physical Sciences Inc. (United States)
Teoman E. Ustun, Physical Sciences Inc. (United States)
Gary D. Noojin, Northrop Grumman Corp. (United States)
David J. Stolarski, Northrop Grumman Corp. (United States)
Harvey M. Hodnett, Northrop Grumman Corp. (United States)
Michelle L. Imholte, Northrop Grumman Corp. (United States)
Semih S. Kumru, Air Force Research Lab. (United States)
Michelle N. McCall, Duke Univ. Medical Ctr. (United States)
Cynthia A. Toth, Duke Univ. Medical Ctr. (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 6138:
Ophthalmic Technologies XVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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