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Proceedings Paper

Coupled waveguide-surface plasmon resonance biosensors constructed with sub-wavelength grating
Author(s): F.-C. Chien; J.-N. Yih; C.-Y. Lin; K.-L. Lee; Y.-M. Chu; Y.-C. Mao; W.-H. Wang; P.-K. Wei; S.-J. Chen
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Paper Abstract

A coupled waveguide-surface plasmon resonance (CWSPR) biosensor constructed with sub-wavelength grating structure is developed and used to analyze biomolecular interaction in real time. The normal incident white light is coupled into the waveguide layer through the sub-wavelength grating, and hence it has an enhanced wave vector to excite the localized surface plasmons on the metal grating surface. The CWSPR biosensor with the surface plasmon resonance (SPR) mode and the waveguide mode not only retains the same sensing sensitivity as that of a conventional SPR device, but also yields sharper dips in the reflectivity spectrum and therefore provides an improved measurement precision. Moreover, without the limitation of a conventional attenuated total reflection coupler and with the help of normal incidence, the system is more flexible and feasible for protein microarray and imaging applications.

Paper Details

Date Published: 28 February 2006
PDF: 7 pages
Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 60950P (28 February 2006); doi: 10.1117/12.647455
Show Author Affiliations
F.-C. Chien, National Central Univ. (Taiwan)
J.-N. Yih, National Central Univ. (Taiwan)
C.-Y. Lin, National Cheng Kung Univ. (Taiwan)
K.-L. Lee, Institute of Applied Science and Engineering Research (Taiwan)
Y.-M. Chu, Industrial Technology Research Institute (Taiwan)
Y.-C. Mao, Industrial Technology Research Institute (Taiwan)
W.-H. Wang, Industrial Technology Research Institute (Taiwan)
P.-K. Wei, Institute of Applied Science and Engineering Research (Taiwan)
S.-J. Chen, National Cheng Kung Univ. (Taiwan)


Published in SPIE Proceedings Vol. 6095:
Nanobiophotonics and Biomedical Applications III
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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