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Proceedings Paper

Protein profile study of clinical samples of ovarian cancer using high-performance liquid chromatography-laser induced fluorescence (HPLC-LIF)
Author(s): Sameer Kumar Singh; Remila L. Martis; Sujatha; Rani A. Bhat; Pralhad Kushtagi; Lavanya Rai; V.B. Kartha; C. Santhosh
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Paper Abstract

New techniques for the early detection of cancer are fast emerging. This is essential for more effective diagnosis and control of the disease. We have used a High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLCLIF) technique to record chromatograms of proteins in serum and ovarian tissue samples. The recorded chromatograms of normal, benign and malignant samples were analyzed using statistical (Principal Component Analysis) methods. It is shown that chromatograms of the samples can be classified into sets, and a model based on such a classification can be used to analyze protein profiles of test samples of serum and ovarian tissue for the detection of malignancies.

Paper Details

Date Published: 27 February 2006
PDF: 9 pages
Proc. SPIE 6092, Ultrasensitive and Single-Molecule Detection Technologies, 60920N (27 February 2006); doi: 10.1117/12.647321
Show Author Affiliations
Sameer Kumar Singh, Kasturba Medical College, Manipal Academy of Higher Education (India)
Remila L. Martis, Kasturba Medical College, Manipal Academy of Higher Education (India)
Sujatha, Kasturba Medical College, Manipal Academy of Higher Education (India)
Rani A. Bhat, Kasturba Medical College, Manipal Academy of Higher Education (India)
Pralhad Kushtagi, Kasturba Medical College, Manipal Academy of Higher Education (India)
Lavanya Rai, Kasturba Medical College, Manipal Academy of Higher Education (India)
V.B. Kartha, Kasturba Medical College, Manipal Academy of Higher Education (India)
C. Santhosh, Kasturba Medical College, Manipal Academy of Higher Education (India)


Published in SPIE Proceedings Vol. 6092:
Ultrasensitive and Single-Molecule Detection Technologies
Jörg Enderlein; Zygmunt K. Gryczynski, Editor(s)

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