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Proceedings Paper

Biochemical characterization of cell-death via Raman spectroscopy
Author(s): Nagapratima Kunapareddy; Susan Carpenter; James P Freyer; Judith R Mourant
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Paper Abstract

Necrosis is the dominant form of cell-death that results from several modalities of cancer treatment. An estimate of post-treatment necrosis serves as an useful indicator of treatment efficacy and tumor response. A non-invasive means of identifying necrosis would serve as a useful clinical tool. In this study, we use Raman spectroscopy for the biochemical characterization of necrosis. Necrosis formation in tissue has been modeled in vitro by the use of multicellular spheroids. The relative amounts of various biochemical components have been estimated and correlated with quantitative estimates of necrosis.

Paper Details

Date Published: 27 February 2006
PDF: 11 pages
Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930V (27 February 2006); doi: 10.1117/12.647232
Show Author Affiliations
Nagapratima Kunapareddy, Boston Univ. (United States)
Susan Carpenter, Los Alamos National Lab. (United States)
James P Freyer, Los Alamos National Lab. (United States)
Judith R Mourant, Los Alamos National Lab. (United States)

Published in SPIE Proceedings Vol. 6093:
Biomedical Vibrational Spectroscopy III: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang H. Petrich, Editor(s)

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