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Proceedings Paper

Magnetic resonance temperature imaging of nanoshell photo-thermal therapy
Author(s): D. Patrick O'Neal; R. Jason Stafford; John D. Hazle
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Paper Abstract

A novel thermal therapy delivery technique using low power near infrared irradiation delivered to a distribution of gold-silica nanoshell particles under MR-guidance has been recently introduced. This research expands upon the previous research by using MR temperature imaging as a tool to investigate the spatiotemporal temperature distribution associated with accumulations of nanoshells after an intravenous injection of nanoshells into tumor bearing mice. Tumors were inoculated and grown subcutaneously in mice and intravenously injected nanoshells were allowed to accumulate passively through the associated leaky vasculature. MRI was used in the planning and post-therapy evaluation of treated sites while realtime MR temperature imaging (MRTI) monitored the distribution of temperature within tissue during the procedure. MRTI was demonstrated to be an excellent tool for determining the extent of thermal energy delivered to the treatment region and could be useful for evaluating the efficiency of nanoshell uptake into a target tissue. This preliminary data demonstrates the feasibility of using MR-guidance for the control of in vivo nanoshell-based photo-thermal therapy. Furthermore, this feasibility study validates previous research that nanoshells will passively accumulate in tumor target tissues at clinically relevant concentrations.

Paper Details

Date Published: 28 February 2006
PDF: 8 pages
Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 609505 (28 February 2006); doi: 10.1117/12.647184
Show Author Affiliations
D. Patrick O'Neal, Nanospectra Biosciences, Inc. (United States)
R. Jason Stafford, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
John D. Hazle, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 6095:
Nanobiophotonics and Biomedical Applications III
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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