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Proceedings Paper

Responses of cultured neuronal network to different electrical stimuli patterns
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Paper Abstract

Learning a new behavioral task is an exploration process that involves the formation and modulation of sets of associations between stimuli and network's responses. The dissociated rat hippocampal neurons were cultured on a multi-electrode array (MEA) substrate. So the electrophysiological activity can be extracellularly recorded, the response of network dynamics induced by electrical pulse stimulation can be analyzed using the recorded data. The test stimuli patterns were different interval twice stimuli. Each stimulus is voltage-controlled pulses (100μs at +0.6V, followed by 100μs at -0.6V). With the intervals between two stimuli decreasing such as a series of 100ms, 50ms, 20ms and 10ms, the response duration of cultured neuronal network increased. The firing rate of neuronal network was affected by the stimuli patterns: compare with the spontaneous firings of neurons, after the quick electrical stimulation (10ms interval stimuli pattern), the firing rate of neuronal network increases. On the contrary, the slow electrical stimulation (100ms interval stimuli pattern) depresses the firing rate of neuronal network.

Paper Details

Date Published: 3 March 2006
PDF: 8 pages
Proc. SPIE 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III, 60850G (3 March 2006); doi: 10.1117/12.647176
Show Author Affiliations
Lin Chen, Huazhong Univ. of Science and Technology (China)
Chuanping Chen, Huazhong Univ. of Science and Technology (China)
Yunsheng Lin, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6085:
Complex Dynamics and Fluctuations in Biomedical Photonics III
Valery V. Tuchin, Editor(s)

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