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Proceedings Paper

Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA
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Paper Abstract

Many mammalian neuronal networks, such as Central Nervous System (CNS), fire single spikes and complex spike burst. In fact, the conditions for triggering burst are not well understood. In the paper multi-electrode array (MEA) is used to record the spontaneous electrophysiology activity of cultured rat hippocampal neuronal networks for long-term. The transition from single spikes to burst is observed on networks that is cultured about 3 weeks and quickly fire before burst activity. The firing rate during burst is lower than that before burst, but the difference of inter spike intervals (ISIs) between the two firing patterns is not distinctness. Moreover, the electrical activities on neighboring electrodes show strong synchrony during burst activity. In a word, the generation of burst requires that network has a sufficient level of excitation as well as the balance by synaptic inhibition.

Paper Details

Date Published: 3 March 2006
PDF: 11 pages
Proc. SPIE 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III, 60850F (3 March 2006); doi: 10.1117/12.647101
Show Author Affiliations
Chuanping Chen, Huazhong Univ. of Science and Technology (China)
Lin Chen, Huazhong Univ. of Science and Technology (China)
Yunsheng Lin, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6085:
Complex Dynamics and Fluctuations in Biomedical Photonics III
Valery V. Tuchin, Editor(s)

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