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Proceedings Paper

Design of an in vivo multi-spectral confocal microendoscope for clinical trials
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Paper Abstract

We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.

Paper Details

Date Published: 23 February 2006
PDF: 8 pages
Proc. SPIE 6082, Endoscopic Microscopy, 608205 (23 February 2006); doi: 10.1117/12.646913
Show Author Affiliations
Andrew R. Rouse, Optical Science Ctr., Univ. of Arizona (United States)
Univ. of Arizona (United States)
Anthony A. Tanbakuchi, Optical Science Ctr., Univ. of Arizona (United States)
Univ. of Arizona (United States)
Joshua A. Udovich, Optical Science Ctr., Univ. of Arizona (United States)
Univ. of Arizona (United States)
Arthur F. Gmitro, Optical Science Ctr., Univ. of Arizona (United States)
Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 6082:
Endoscopic Microscopy
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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