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Proceedings Paper

Comparison of Lorentzian- and Gaussian-based approaches for laser speckle imaging of blood flow dynamics
Author(s): Julio C. Ramirez-San-Juan; J. Stuart Nelson; Bernard Choi
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Paper Abstract

Since blood flow is tightly coupled to the health status of biological tissue, several instruments have been developed to monitor blood flow and perfusion dynamics. One such instrument is laser speckle imaging (LSI). The objective of this work is to evaluate an LSI instrument employing two statistically based approaches to calculate the speckle flow index (SFI). To study the relation between SFI and the actual flow rate for the two statistical approaches, speckle images were acquired from a 0.5% blood filled tube embedded within a 5 mm thick agar gel. A syringe based infusion pump was used to inject the blood at flow rates between 0 and 5 mm/sec. We found a linear relationship between SFI and actual flow rate for both the Gaussian and Lorentzian based approaches. With the Gaussian based approach, the SFI dynamic range was up to six times larger than with the Lorentzian based approach. The Gaussian based approach is a good alternative for computation of SFI using LSI.

Paper Details

Date Published: 20 February 2006
PDF: 4 pages
Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 607924 (20 February 2006); doi: 10.1117/12.646891
Show Author Affiliations
Julio C. Ramirez-San-Juan, Instituto Nacional de Astrofísica, Óptica y Electrónica (Mexico)
J. Stuart Nelson, Beckman Laser Institute (United States)
Bernard Choi, Beckman Laser Institute (United States)

Published in SPIE Proceedings Vol. 6079:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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