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Proceedings Paper

Multimodal multiplex Raman spectroscopy optimized for in vivo chemometrics
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Paper Abstract

We have designed and constructed a multimodal multiplex Raman spectrometer which uses multi-wavelength excitation to better detect signals in the presence of fluorescence by taking advantage of the shift-variance of the Raman signal with respect to excitation frequency. Coupled with partial-least-squares (PLS) regression, the technique applied to ethanol estimation in a tissue phantom achieves root-mean-squared-cross-validation errors (RMSCVE) of 9.2 mmol/L with a model formed with 2 principal components, compared to a single wavelength data set with equivalent energy where 7 principal components were used to achieve an RMSCVE of 39.1 mmol/L.

Paper Details

Date Published: 27 February 2006
PDF: 8 pages
Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930P (27 February 2006); doi: 10.1117/12.646755
Show Author Affiliations
S. T. McCain, Duke Univ. (United States)
M. E. Gehm, Duke Univ. (United States)
Y. Wang, Duke Univ. (United States)
N. P. Pitsianis, Duke Univ. (United States)
D. J. Brady, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 6093:
Biomedical Vibrational Spectroscopy III: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang H. Petrich, Editor(s)

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