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Proceedings Paper

Time-domain terahertz spectroscopy of artificial skin
Author(s): Peter M. Corridon; Ricardo Ascázubi; Courtney Krest; Ingrid Wilke
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Paper Abstract

Time-domain Terahertz (THz) spectroscopy and imaging is currently evaluated as a novel tool for medical imaging and diagnostics. The application of THz-pulse imaging of human skin tissues and related cancers has been demonstrated recently in-vitro and in-vivo. With this in mind, we present a time-domain THz-transmission study of artificial skin. The skin samples consist of a monolayer of porous matrix of fibers of cross-linked bovine tendon collagen and a glycosaminoglycan (chondroitin-6-sulfate) that is manufactured with a controlled porosity and defined degradation rate. Another set of samples consists of the collagen monolayer covered with a silicone layer. We have measured the THz-transmission and determined the index of refraction and absorption of our samples between 0.1 and 3 THz for various states of hydration in distilled water and saline solutions. The transmission of the THz-radiation through the artificial skin samples is modeled by electromagnetic wave theory. Moreover, the THz-optical properties of the artificial skin layers are compared to the THz-optical properties of freshly excised human skin samples. Based on this comparison the potential use of artificial skin samples as photo-medical phantoms for human skin is discussed.

Paper Details

Date Published: 25 February 2006
PDF: 12 pages
Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608007 (25 February 2006); doi: 10.1117/12.646632
Show Author Affiliations
Peter M. Corridon, Rensselaer Polytechnic Institute (United States)
Ricardo Ascázubi, Rensselaer Polytechnic Institute (United States)
Courtney Krest, St. John Fisher College (United States)
Ingrid Wilke, Rensselaer Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 6080:
Advanced Biomedical and Clinical Diagnostic Systems IV
Gerald E. Cohn; Warren S. Grundfest; David A. Benaron; Tuan Vo-Dinh, Editor(s)

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