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Proceedings Paper

Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)
Author(s): Susanne D. Giattina; Brian K. Courtney; Paul R. Herz; Michelle Harman; Sonya Shortkroff; Debra L. Stamper; Bin Liu; James G. Fujimoto; Mark E. Brezinski
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Paper Abstract

Current evidence indicates that most plaques classified as vulnerable or ruptured plaques do not lead to unstable angina or myocardial infarction. Improved methods are needed to risk stratify plaques to identify those which lead to most acute coronary syndromes. Collagen depletion in the intima overlying lipid collections appears to be a critical component of unstable plaques. In this study, we use polarization sensitive optical coherence tomography (PS-OCT) for the assessment of coronary plaque collagen. Collagen is birefringent, meaning that different polarization states travel through it at different velocities. Changes in PS-OCT images are a measure of tissue birefringence. Twenty-two coronary artery segments were imaged with PS-OCT and analyzed by picrosirius staining (a measure of collagen intensity and fiber size) and trichrome blue. The regression plot between PS-OCT changes and measured collagen yielded a correlation coefficient value of 0.475 (p<0.002). Good correlation was noted between two blinded investigators both with respect to PS-OCT measurements as well as luminosity as assessed by picrosirius. The predictive value of a PS-OCT measurement of negligible birefringence (less than 33% change) for minimal collagen was 93% while the predictive value of high birefringence (greater than 66% change) for high collagen concentrations was 89%. The effect of fiber type (chemical composition) was minimal relative to the effect due to fiber concentration. The capability of PS-OCT to assess plaque collagen content, in addition to its ability to generate high resolution structural assessments, make it a potentially powerful technology for identifying high risk plaques.

Paper Details

Date Published: 22 February 2006
PDF: 4 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60782C (22 February 2006); doi: 10.1117/12.646494
Show Author Affiliations
Susanne D. Giattina, Brigham and Women's Hospital (United States)
Brian K. Courtney, Stanford Univ. Medical Ctr. (United States)
Paul R. Herz, Massachusetts Institute of Technology (United States)
Michelle Harman, Brigham and Women's Hospital (United States)
Sonya Shortkroff, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Debra L. Stamper, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Bin Liu, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)
Mark E. Brezinski, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory; Guillermo J. Tearney; Nikiforos Kollias; Haishan Zeng; Bernard Choi; Reza S. Malek; Michael D. Lucroy; Lloyd P. Tate; Henry Hirschberg; Steen J. Madsen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Eugene A. Trowers; Werner T.W. de Riese, Editor(s)

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