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Proceedings Paper

Photosensitizer decorated iron oxide nanoparticles: bimodal agent for combined hyperthermia and photodynamic therapy
Author(s): Zhimou Yang; Keming Xu; Bei Zhang; Bing Xu; Xixiang Zhang; Chi K. Chang
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Paper Abstract

As the PDT effect may be enhanced by localized hyperthermia (HT), it would be logical to find a single agent that could bring about these two modalities at precisely the target site for synergism. Since highly localized HT can be induced by magnetic field excitation of superparamagnetic nanoparticles, we report here the design and synthesis of photosensitizer-decorated iron oxide nanoparticles and their tumoricidal effect. Thus, a porphyrin is covalently anchored on the iron oxide nanoparticle via dihydroxybenzene which binds tightly on the surface of the nanoparticle by M-O bond. The morphology of the resultant nanoparticle was studied to show that the crystallinality is not changed and the nanoparticle remains superparamagnetic at room temperature. The conjugate is also strongly fluorescent indicating that the iron oxide hardly affects the optical properties of the surface bound porphyrin moieties. The conjugate is readily taken by cancer cell (Hela cell line) and is able to trigger apoptosis after excitation by light.

Paper Details

Date Published: 6 March 2006
PDF: 10 pages
Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613906 (6 March 2006); doi: 10.1117/12.646341
Show Author Affiliations
Zhimou Yang, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Keming Xu, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Bei Zhang, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Bing Xu, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Xixiang Zhang, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Chi K. Chang, The Hong Kong Univ. of Science and Technology (Hong Kong China)


Published in SPIE Proceedings Vol. 6139:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
David Kessel, Editor(s)

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