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Proceedings Paper

Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells
Author(s): Chi K. Chang; Pak-Wing Kong; Hai-Yang Liu; Lam-Lung Yeung; Ho-Kee Koon; Nai-Ki Mak
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Paper Abstract

Ten trans-A2B and A3-type corrole photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroles containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corrole derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

Paper Details

Date Published: 6 March 2006
PDF: 11 pages
Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613915 (6 March 2006); doi: 10.1117/12.646328
Show Author Affiliations
Chi K. Chang, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Pak-Wing Kong, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Hai-Yang Liu, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Lam-Lung Yeung, The Hong Kong Univ. of Science and Technology (Hong Kong China)
Ho-Kee Koon, Hong Kong Baptist Univ. (Hong Kong China)
Nai-Ki Mak, Hong Kong Baptist Univ. (Hong Kong China)


Published in SPIE Proceedings Vol. 6139:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
David Kessel, Editor(s)

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