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Proceedings Paper

Tip-enhanced Raman scattering of a DNA binding compound
Author(s): Akiko Rasmussen; Christian Budich; Volker Deckert
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Paper Abstract

Tip-enhanced Raman scattering (TERS), a scattering type scanning near-field optical microscope (s-SNOM), is a technique which combines Raman spectroscopy with an optically active silver coated scanning probe microscopy tip. Only the molecules located in a small area close to the tip apex will experience the field enhancement. This provides a unique tool to obtain highly enhanced Raman signals together with a high lateral-resolution. In this paper, preliminary investigation of the interaction between methylene blue and calf-thymus double-stranded (ds) DNA has been carried out by SERS. Furthermore, TERS spectra of methylene blue have been collected for the first time, and are compared with standard surface enhanced Raman scattering (SERS). The results are discussed in terms of possible biological applications.

Paper Details

Date Published: 27 February 2006
PDF: 8 pages
Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930Z (27 February 2006); doi: 10.1117/12.646274
Show Author Affiliations
Akiko Rasmussen, Institute for Analytical Sciences (Germany)
Christian Budich, Institute for Analytical Sciences (Germany)
Volker Deckert, Institute for Analytical Sciences (Germany)


Published in SPIE Proceedings Vol. 6093:
Biomedical Vibrational Spectroscopy III: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang H. Petrich, Editor(s)

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