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Proceedings Paper

Two-photon triggered drug delivery system: a new way to prevent posterior capsule opacification
Author(s): H.-C. Kim; S. Härtner; N. Hampp
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Paper Abstract

One of the major complications of cataract surgery is posterior capsule opacification caused by proliferation and migration of residual lens epithelial cells into the visual axis. In this study we present a novel approach to treat posterior capsule opacification in a non-invasive manner. A polymer-drug conjugate has been developed which is suitable for manufacturing functional intraocular lenses equipped with a drug delivery system. The therapeutic molecules, 5-fluorouracil, were attached through a photolabile linkage to the acrylic polymer backbone of the intraocular lens material. The controlled release of 5-fluorouracil is accomplished by two-photon induced cleavage of the linkage which is stable in ordinary conditions. The properties of the therapeutic system are characterized and the function is demonstrated in in vitro tests. The utilization of two-photon-absorption processes in drug delivery may provide a powerful tool to prevent posterior capsule opacification.

Paper Details

Date Published: 7 March 2006
PDF: 8 pages
Proc. SPIE 6138, Ophthalmic Technologies XVI, 61380S (7 March 2006); doi: 10.1117/12.646098
Show Author Affiliations
H.-C. Kim, Univ. of Marburg (Germany)
S. Härtner, Univ. of Marburg (Germany)
N. Hampp, Univ. of Marburg (Germany)
Material Sciences Ctr. Marburg (Germany)


Published in SPIE Proceedings Vol. 6138:
Ophthalmic Technologies XVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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