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Proceedings Paper

In vivo multiphoton tomography of skin cancer
Author(s): Karsten König; Iris Riemann; Alexander Ehlers; Rainer Buckle; Enrico Dimitrow; Martin Kaatz; Joachim Fluhr; Peter Elsner
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Paper Abstract

The multiphoton tomograph DermaInspect was used to perform first clinical studies on the early non-invasive detection of skin cancer based on non-invasive optical sectioning of skin by two-photon autofluorescence and second harmonic generation. In particular, deep-tissue pigmented lesions -nevi- have been imaged with intracellular resolution using near infrared (NIR) femtosecond laser radiation. So far, more than 250 patients have been investigated. Cancerous tissues showed significant morphological differences compared to normal skin layers. In the case of malignant melanoma, the occurrence of luminescent melanocytes has been detected. Multiphoton tomography will become a novel non-invasive method to obtain high-resolution 3D optical biopsies for early cancer detection, treatment control, and in situ drug screening.

Paper Details

Date Published: 23 February 2006
PDF: 7 pages
Proc. SPIE 6089, Multiphoton Microscopy in the Biomedical Sciences VI, 60890R (23 February 2006); doi: 10.1117/12.646000
Show Author Affiliations
Karsten König, Fraunhofer Institute of Biomedical Technology (Germany)
Iris Riemann, Fraunhofer Institute of Biomedical Technology (Germany)
Alexander Ehlers, Fraunhofer Institute of Biomedical Technology (Germany)
Rainer Buckle, JenLab GmbH (Germany)
Enrico Dimitrow, Univ. Jena (Germany)
Martin Kaatz, Univ. Jena (Germany)
Joachim Fluhr, Univ. Jena (Germany)
Peter Elsner, Univ. Jena (Germany)

Published in SPIE Proceedings Vol. 6089:
Multiphoton Microscopy in the Biomedical Sciences VI
Ammasi Periasamy; Peter T. C. So, Editor(s)

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