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Proceedings Paper

Laser-induced enhancement of transdermal drug delivery for lidocaine through hairless mouse skin
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Paper Abstract

Transdermal drug delivery system (TDDS), which is one of drug delivery system (DDS) for increasing the effectiveness of drugs, is enhanced absorption of drugs by laser irradiation. The purpose of this study is to investigate the optimum laser parameter for enhancing TDD and to examine the mechanism of TDD enhancement. In this study, hairless mouse skins (in vitro) were irradiated with Er:YAG laser, Nd:YAG laser and free electron laser (FEL), which were set up energy density of 0.5 J/cm2/pulse and exposure time of 5 second. We examined the flux (μg/cm2/h) of lidocaine (C14H22N2O, FW: 234.38) through the skins using high pressure liquid chromatography (HPLC), observed cross section of the irradiated samples using light microscope, and measured electrical resistance of the surface of skins. The HPLC results demonstrated that the TDD of the irradiated samples was enhanced 200-350 times faster than it of the non-irradiated samples. It of Nd:YAG laser, however, had no enhancement. The observation of cross section and the electrical resistance of skins were found to not remove the stratum corneum (SC), completely. These results show that laser irradiations, which has the strong absorption to skins, enhance TDD dramatically with low invasive.

Paper Details

Date Published: 23 February 2006
PDF: 8 pages
Proc. SPIE 6087, Biophotonics and Immune Responses, 60870Q (23 February 2006); doi: 10.1117/12.645594
Show Author Affiliations
Takeyuki Uchizono, Osaka Univ. (Japan)
Kunio Awazu, Osaka Univ. (Japan)


Published in SPIE Proceedings Vol. 6087:
Biophotonics and Immune Responses
Wei R. Chen, Editor(s)

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