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Proceedings Paper

In vivo functional photoacoustic imaging of brain tumor vasculature
Author(s): Jung-Taek Oh; Meng-Lin Li; Xueyi Xie; George Stoica; Lihong V. Wang
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Paper Abstract

We present a study of the functional photoacoustic imaging of tumor hypoxia in mice in vivo. Based on spectroscopic photoacoustic tomography that detects the optical absorption of oxy- and deoxy-hemoglobins, the blood oxygen saturation and the vascularization of brain tumors were visualized. U87 glioblastoma tumor cells were inoculated intracranially at a 3-mm depth from the surface of the nude mouse head seven days before the experiment. Increased blood content and hypoxia inside the tumor vasculature were detected through the intact skin and skull. This technique will be useful for future studies on tumor metabolic activities in the brain and hypoxia-related therapeutic resistance.

Paper Details

Date Published: 6 March 2006
PDF: 7 pages
Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860C (6 March 2006); doi: 10.1117/12.645391
Show Author Affiliations
Jung-Taek Oh, Texas A&M Univ. (United States)
Meng-Lin Li, Texas A&M Univ. (United States)
Xueyi Xie, Texas A&M Univ. (United States)
George Stoica, Texas A&M Univ. (United States)
Lihong V. Wang, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 6086:
Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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