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Proceedings Paper

NAOMI: nanoparticle assisted optical molecular imaging
Author(s): Dirk J. Faber; Mirjam E. J. van Velthoven; Martijn de Bruin; Maurice C. G. Aalders; Frank D. Verbraak; Christina Graf; Ton G. van Leeuwen
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Paper Abstract

Our first steps towards nanoparticle assisted, optical molecular imaging (NAOMI) using OCT as the imaging modality are presented. We derive an expression to estimate the sensitivity of this technique. We propose to use nanoparticles based on biodegradable polymers, loaded with suitable dyes as contrast agent, and outline a method for establishing their desired optical properties prior to synthesis. This report presents preliminary results of our investigation on the use of nanoshells to serve as contrast agents We injected nanoshells with specific contrast features in the 800 nm wavelength region in excised porcine eyes. The nanoshells showed up as bright reflecting structures in the OCT images, which confirm their potential as contrast agents.

Paper Details

Date Published: 20 February 2006
PDF: 9 pages
Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 607905 (20 February 2006); doi: 10.1117/12.645316
Show Author Affiliations
Dirk J. Faber, Academic Medical Ctr. (Netherlands)
Mirjam E. J. van Velthoven, Academic Medical Ctr. (Netherlands)
Martijn de Bruin, Academic Medical Ctr. (Netherlands)
Maurice C. G. Aalders, Academic Medical Ctr. (Netherlands)
Frank D. Verbraak, Academic Medical Ctr. (Netherlands)
Christina Graf, Univ. Wurzburg (Germany)
Ton G. van Leeuwen, Academic Medical Ctr. (Netherlands)
Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 6079:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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