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Proceedings Paper

Full-field high-speed laser Doppler imaging system for blood-flow measurements
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Paper Abstract

We describe the design and performance of a new full-field high-speed laser Doppler imaging system developed for mapping and monitoring of blood flow in biological tissue. The total imaging time for 256x256 pixels region of interest is 1.2 seconds. An integrating CMOS image sensor is utilized to detect Doppler signal in a plurality of points simultaneously on the sample illuminated by a divergent laser beam of a uniform intensity profile. The integrating property of the detector improves the signal-to-noise ratio of the measurement, which results in high-quality flow-images provided by the system. The new technique is real-time, non-invasive and the instrument is easy to use. The wide range of applications is one of the major challenges for a future application of the imager. High-resolution high-speed laser Doppler perfusion imaging is a promising optical technique for diagnostic and assessing the treatment effect of the diseases such as e.g. atherosclerosis, psoriasis, diabetes, skin cancer, allergies, peripheral vascular diseases, skin irritancy and wound healing. We present some biological applications of the new imager and discuss the perspectives for the future implementations of the imager for clinical and physiological applications.

Paper Details

Date Published: 25 February 2006
PDF: 8 pages
Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608004 (25 February 2006); doi: 10.1117/12.645205
Show Author Affiliations
Alexandre Serov, Lab. d'Optique Biomédicale, École Polytechnique Fédérale de Lausanne (Switzerland)
Theo Lasser, Lab. d'Optique Biomédicale, École Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 6080:
Advanced Biomedical and Clinical Diagnostic Systems IV
Gerald E. Cohn; Warren S. Grundfest; David A. Benaron; Tuan Vo-Dinh, Editor(s)

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