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Proceedings Paper

Investigation of photodynamic activity of water-soluble porphyrins in vitro and in vivo
Author(s): Grigor V. Gyulkhandanyan; Sona S. Ghambaryan; Gayane V. Amelyan; Robert K. Ghazaryan; Flora H. Arsenyan; Aram G. Gyulkhandanyan
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Paper Abstract

Photodynamic therapy (PDT) is the method of photosensitized tumor treatment. It is based on the photosensitizer (PS) selective accumulation in tumors, its subsequent activation under the light influence and oxygen active form formation that results in tumor destruction. Photodynamic action of some new water-soluble porphyrins was investigated in our laboratory. Dose-dependent effect of these porphyrins was shown on PC-12 murine pheochromocytoma cell line. The results revealed that the efficiency of the investigated porphyrins decreased in the following way: TOEPyP (meso-tetra-(4-N-oxyethylpyridyl)porphyrin) > Zn-TOEPyP > Ag-TOEPyP. It was shown that TOEPyP possessed nearly the same photodynamic activity (LD50) as well-known photosensitizer chlorin e6. These porphyrins have also demonstrated quite high photodynamic activity in vivo. The results were obtained in the experiments on white mice with engrafted C-180 (Croker's sarcoma). Antitumor activity of these porphyrins in the dark was 30-40%, whereas photodynamic activity was 45-60%.

Paper Details

Date Published: 6 March 2006
PDF: 7 pages
Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613911 (6 March 2006); doi: 10.1117/12.645053
Show Author Affiliations
Grigor V. Gyulkhandanyan, Institute of Biotechnology (Armenia)
Pharmagene Co. Ltd. (Armenia)
Sona S. Ghambaryan, Institute of Biotechnology (Armenia)
Gayane V. Amelyan, Institute of Biotechnology (Armenia)
Robert K. Ghazaryan, Yerevan State Medical Univ. (Armenia)
Flora H. Arsenyan, Institute of Fine Organic Chemistry (Armenia)
Aram G. Gyulkhandanyan, Yereven State Univ. (Armenia)

Published in SPIE Proceedings Vol. 6139:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
David Kessel, Editor(s)

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