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Proceedings Paper

Design of controlled drug delivery system with optimal release characteristics
Author(s): Xiaopeng Wang; Tianning Chen; Zhanxiao Yang; Wanjun Wang
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Paper Abstract

The biodegradable controlled-release system with large array of micro chambers is a new controlled drug delivery system. The structure of the system is designed using the MEMS technology, combining the drug release condition and the biodegradable characteristic of the polymer. This type of drug delivery system has some unique advantages in controlled long-term drug delivery, such as more drug loading than the matrices release systems, easier control the release rate, and so on. It is necessary to optimum the structure for the long-term drug delivery. This paper founds the simulated modeling which can simulate the erosion and the drug delivery from this controlled-release system. Further more the thickness of the chamber's wall is taken as the design variable. An optimized modeling for the drug delivery from the biodegradable controlled-release system is developed. This model can optimize the structure of the controlled release system for the desired release characteristics. The results indicate that this method can be used to design the drug delivery system based on the biodegradable polymer.

Paper Details

Date Published: 23 January 2006
PDF: 8 pages
Proc. SPIE 6112, Microfluidics, BioMEMS, and Medical Microsystems IV, 61120Q (23 January 2006); doi: 10.1117/12.644077
Show Author Affiliations
Xiaopeng Wang, Xi'an Jiaotong Univ. (China)
Tianning Chen, Xi'an Jiaotong Univ. (China)
Zhanxiao Yang, Xi'an Jiaotong Univ. (China)
Wanjun Wang, Louisiana State Univ. (United States)


Published in SPIE Proceedings Vol. 6112:
Microfluidics, BioMEMS, and Medical Microsystems IV
Ian Papautsky; Wanjun Wang, Editor(s)

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