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Proceedings Paper

Design and fabrication of a disposable, percutaneous glucose sensor
Author(s): Kuo-Chih Liao; Thieo Hogen-Esch; Frances J. Richmond; Laura Marcu; William Clifton; Gerald E. Loeb
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Paper Abstract

Sencilstm (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Paper Details

Date Published: 15 February 2006
PDF: 9 pages
Proc. SPIE 6083, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI, 60830V (15 February 2006); doi: 10.1117/12.643990
Show Author Affiliations
Kuo-Chih Liao, Univ. of Southern California (United States)
Thieo Hogen-Esch, Univ. of Southern California (United States)
Frances J. Richmond, Univ. of Southern California (United States)
Laura Marcu, Univ. of Southern California (United States)
William Clifton, Univ. of Southern California (United States)
Gerald E. Loeb, Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 6083:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI
Israel Gannot, Editor(s)

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