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Proceedings Paper

Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography
Author(s): A. D. Aguirre; Y. Chen; L. Ruvinskaya; A. Devor; D. A. Boas; J. G. Fujimoto
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Paper Abstract

Simultaneous optical coherence tomography (OCT) and video microscopy were performed on the rat somatosensory cortex through a thinned skull during forepaw stimulation. Fractional change measurements in OCT images reveal a functional signal timecourse similar to well understood hemodynamic signal timecourses measured with video microscopy. The precise etiology of the observed OCT functional signal is still under investigation, but these results suggest that OCT can provide high-resolution cross-sectional images of functional neuro-vascular activation.

Paper Details

Date Published: 7 October 2005
PDF: 4 pages
Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58611D (7 October 2005); doi: 10.1117/12.641798
Show Author Affiliations
A. D. Aguirre, Massachusetts Institute of Technology (United States)
Harvard-MIT Division of Health Sciences and Technology (United States)
Y. Chen, Massachusetts Institute of Technology (United States)
L. Ruvinskaya, Massachusetts General Hospital, Harvard Medical School (United States)
A. Devor, Massachusetts General Hospital, Harvard Medical School (United States)
D. A. Boas, Harvard-MIT Division of Health Sciences and Technology (United States)
Massachusetts General Hospital, Harvard Medical School (United States)
J. G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 5861:
Optical Coherence Tomography and Coherence Techniques II
Wolfgang Drexler, Editor(s)

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