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Proceedings Paper

Nonsensitized photoinduced destruction of tumor in experiments
Author(s): B. M. Dzhagarov; S. A. Bizyuk; M. V. Parkhats; E. A. Zhavrid; Yu. P. Istomin
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Paper Abstract

The sizeable damage of tumor (Pliss lymphosarcoma) were detected on intact rats (without the photosensitizer injection) after laser excitation (λ=627.8 nm or λ=671 nm). The model is suggested to calculate the absolute and relative sizes of the tumor node necrosis and the area of the histotopographic section. The photon distribution between photosensitizer and hemoglobin molecules is calculated for the typical PDT conditions. We suppose that some non-photodynamic reactions activated by light are responsible for the observed photodestructive effect on intact tumors. The contribution of these reactions to the tumor damage in PDT treatments is considerable and it cannot be neglected.

Paper Details

Date Published: 7 December 2006
PDF: 6 pages
Proc. SPIE 5973, Current Research on Laser Use in Oncology: 2000-2004, 59730S (7 December 2006); doi: 10.1117/12.640144
Show Author Affiliations
B. M. Dzhagarov, Institute of Molecular and Atomic Physics NAS (Belarus)
S. A. Bizyuk, Institute of Molecular and Atomic Physics NAS (Belarus)
M. V. Parkhats, Institute of Molecular and Atomic Physics NAS (Belarus)
E. A. Zhavrid, N.N. Aleksandrov Scientific-Research Institute of Oncology and Medicinal Radiology (Belarus)
Yu. P. Istomin, N.N. Aleksandrov Scientific-Research Institute of Oncology and Medicinal Radiology (Belarus)


Published in SPIE Proceedings Vol. 5973:
Current Research on Laser Use in Oncology: 2000-2004
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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